After talks with his Russian counterpart Vladimir Putin in Moscow on April 26, Karimov also said the Shanghai Cooperation Organization must not be involved in the military and political stand-off in Afghanistan.
Karimov noted that the renewal of peace talks between the Afghan government and Taliban is "important" for the whole region.
Afghanistan, Pakistan, China, and the United States have been unsuccessfully trying to revive peace talks between Kabul and the Taliban in recent months.
According to Karimov, "instability in Afghanistan" may gradually spread to other countries of the region.
Putin said that Russia and Uzbekistan support the creation of an international antiterrorist coalition.
Karimov arrived on April 25 in Moscow for a two-day visit.